# Sermorelin for women: benefits, risks and evidence Updated November 3, 2026. Canonical: https://try-astra.com/sermorelin/guides/for-women/ **Sermorelin at Astra:** $91/mo on the 6-month plan ($546 every 6 months) or $120/mo on the monthly plan. Includes medication, provider visit, supplies and shipping. Full refund if a provider does not prescribe. Pay by card or Apple Pay, or over time with Klarna, Afterpay or Affirm at checkout. Prescription required. Compounded medications are not FDA-approved. [Start a visit](https://start.try-astra.com/start-online-visit/sermorelin). ## The short answer **Women can be prescribed sermorelin when a provider decides it is appropriate, but research in women is limited to two small studies, neither using sermorelin itself.** Growth hormone and IGF-1 rose in one, and skin thickness increased, while body weight and muscle did not change. In the other, a different GHRH molecule reduced visceral fat, with no control group. It should not be used in pregnancy or while breastfeeding, and compounded sermorelin is not FDA-approved. ## Why a provider review matters for women - **Your hormones are part of the picture.** Tell your provider about any hormone therapy, menopause symptoms or plans for pregnancy. - **Honest expectations.** You can discuss which goals have some evidence and which do not before you spend money. - **Care from home.** An online visit, a licensed US provider, and delivery to your door. > I was skeptical at first, but Sermorelin has exceeded my expectations. The Astra team made the whole process seamless. > Jennifer L., 38, Austin, TX. Astra patient, 2 months on sermorelin. One patient's experience, not a typical or guaranteed result. Individual results vary. **Considering sermorelin?** A licensed provider reviews your answers and decides whether it is appropriate. See how it compares on price in the [sermorelin price index](/sermorelin-price-index/), or read about the [sermorelin program](/sermorelin/). [Start your sermorelin visit](https://start.try-astra.com/start-online-visit/sermorelin). $120 charged monthly, or $546 every 6 months ($91/mo). Renews automatically; cancel any time. Full refund if a provider does not prescribe. [Subscription terms](/subscription-terms/). ## What the trial found in women The [1997 Khorram trial](https://pubmed.ncbi.nlm.nih.gov/9141536/) gave a GHRH analog for 16 weeks to 10 women and 9 men aged 55 to 71. The results differed by sex: | Measure | Women | Men | |---|---|---| | GH and IGF-1 | Increased | Increased | | Skin thickness | Increased | Increased | | Lean body mass | No increase | Increased | | Insulin sensitivity | No increase | Increased | | General well-being and libido | No improvement | Improved | | Body weight | Unchanged | Unchanged | | Sleep quality | Unchanged | Unchanged | That is a very small group, in one age range, decades ago. It cannot tell you what to expect at a younger age or on a compounded product. ## The study in postmenopausal women In [a 2005 study](https://pubmed.ncbi.nlm.nih.gov/16260425/), 10 postmenopausal women took GHRH-1,44, the full-length molecule rather than sermorelin's 29-amino-acid fragment, for 3 months. Overnight GH rose about 98% and IGF-1 about 71%. Visceral fat fell 16%, and walking and stair-climbing times improved. Most participants (70%) had skin reactions at the injection site. There was no placebo group, so these results compare women with their own starting point, and they cannot simply be applied to sermorelin. ## Who should not take it The [Geref label](https://assets.hpra.ie/products/Human/16600/LicenseSPC_PA0285-006-001_13072006155719.pdf) lists pregnancy and lactation as contraindications. [Astra's sermorelin page](/sermorelin/) also says it is not recommended if you have active cancer or certain pituitary conditions. See [is sermorelin safe?](/sermorelin/guides/is-it-safe/) for the full list, and tell your provider about any hormone treatment you use. ## Claims that go beyond the evidence - **Menopause and anti-aging.** A [review of growth hormone, menopause and ageing](https://pubmed.ncbi.nlm.nih.gov/19228699/) found no definite evidence of rejuvenation with GH. - **Belly fat and weight loss.** Body weight did not change in the 1997 trial. The 2005 study above is not a sermorelin trial and had no control group. See [sermorelin and weight loss](/sermorelin/guides/weight-loss/). - **Better sleep.** Sleep quality did not change in this trial. See [sermorelin and sleep](/sermorelin/guides/sleep/). ## Common questions ### Does sermorelin work for women? A related analog raised GH and IGF-1 in a small trial. Most other benefits measured in that trial were seen only in men, or not at all. ### Will sermorelin help with belly fat? We did not find a trial of sermorelin itself showing this. [One uncontrolled study](https://pubmed.ncbi.nlm.nih.gov/16260425/) of a different GHRH molecule reported 16% less visceral fat in 10 postmenopausal women. See [sermorelin and weight loss](/sermorelin/guides/weight-loss/). ### What is the best peptide for women? No evidence-based ranking exists. The better question is whether a treatment has been studied for your goal and suits your health history, which a licensed provider can assess. ### Can I take sermorelin while trying to get pregnant? Talk to your provider first. The [Geref label](https://assets.hpra.ie/products/Human/16600/LicenseSPC_PA0285-006-001_13072006155719.pdf) rules out use during pregnancy. ## Safety at a glance Reported side effects include flushing, injection site pain or irritation and mild headache. Sermorelin is not recommended in pregnancy or breastfeeding, active cancer or certain pituitary conditions, and long-term safety in adults has not been established. It is [prohibited in tested sports](https://www.wada-ama.org/sites/default/files/2024-09/2025list_en_final_clean_12_september_2024.pdf). Read [is sermorelin safe?](/sermorelin/guides/is-it-safe/) for sources and details. ## Keep reading - [All sermorelin guides](/sermorelin/guides/) - [Sermorelin and weight loss](/sermorelin/guides/weight-loss/): Why it isn't an established weight loss treatment, and how it differs from GLP-1s. - [Is sermorelin safe?](/sermorelin/guides/is-it-safe/): Known side effects, who should avoid it, and what remains unknown. - [Does sermorelin work?](/sermorelin/guides/does-it-work/): What it does, what studies measured, and who it may suit. - [Sermorelin and sleep](/sermorelin/guides/sleep/): The real link between GH and deep sleep, and why it doesn't prove better sleep. **More guides:** [FDA status and legality](/sermorelin/guides/fda-approved-legal/) · [Sermorelin vs tesamorelin](/sermorelin/guides/vs-tesamorelin/) · [Sermorelin online](/sermorelin/guides/online-prescription/) · [Providers compared](/sermorelin/guides/providers-compared/) · [Results timeline](/sermorelin/guides/results-timeline/) · [Sermorelin vs CJC-1295](/sermorelin/guides/vs-cjc-1295/) · [Sermorelin vs HGH](/sermorelin/guides/vs-hgh/) · [Sermorelin with GLP-1s](/sermorelin/guides/with-tirzepatide-or-semaglutide/) · [Stopping sermorelin](/sermorelin/guides/stopping/) ## Sources - [Khorram et al., long-term GHRH analog in age-advanced men and women](https://pubmed.ncbi.nlm.nih.gov/9141536/), J Clin Endocrinol Metab, 1997 - [Veldhuis et al., GHRH-1,44 for 3 months in postmenopausal women](https://pubmed.ncbi.nlm.nih.gov/16260425/), Eur J Endocrinol, 2005 - [Geref 50 summary of product characteristics](https://assets.hpra.ie/products/Human/16600/LicenseSPC_PA0285-006-001_13072006155719.pdf), Health Products Regulatory Authority, Ireland - [Fanciulli et al., Growth hormone, menopause and ageing](https://pubmed.ncbi.nlm.nih.gov/19228699/), 2009 Published by Astra, which offers sermorelin. This guide is educational and is not medical advice. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness or quality.