# Sermorelin results timeline: what was actually measured Updated November 3, 2026. Canonical: https://try-astra.com/sermorelin/guides/results-timeline/ **Sermorelin at Astra:** $91/mo on the 6-month plan ($546 every 6 months) or $120/mo on the monthly plan. Includes medication, provider visit, supplies and shipping. Full refund if a provider does not prescribe. Pay by card or Apple Pay, or over time with Klarna, Afterpay or Affirm at checkout. Prescription required. Compounded medications are not FDA-approved. [Start a visit](https://start.try-astra.com/start-online-visit/sermorelin). ## The short answer **Your body responds quickly at the lab level: GH rises within minutes, and IGF-1 rose within 2 weeks in one trial.** Visible changes are less certain, and body weight did not change in the adult studies we reviewed. Results vary by person, so a useful plan is to agree what you want to track with your provider before you start. ## What to expect with a provider - **Agree your goals first.** Tell your provider what you hope will change, so you can judge whether to continue. - **Track what can be measured.** IGF-1 is a blood marker for GH activity, and your provider can advise on testing. - **Review as you go.** Your care team stays available, and you can cancel your plan at any time. > As someone who's always been active, the decline in recovery time and muscle tone as I hit my 50s was frustrating. Sermorelin has genuinely helped me regain ground. > David K., 53, Portland, OR. Astra patient, 4 months on sermorelin. One patient's experience, not a typical or guaranteed result. Individual results vary. **Considering sermorelin?** A licensed provider reviews your answers and decides whether it is appropriate. See how it compares on price in the [sermorelin price index](/sermorelin-price-index/), or read about the [sermorelin program](/sermorelin/). [Start your sermorelin visit](https://start.try-astra.com/start-online-visit/sermorelin). $120 charged monthly, or $546 every 6 months ($91/mo). Renews automatically; cancel any time. Full refund if a provider does not prescribe. [Subscription terms](/subscription-terms/). ## What studies measured over time | When | What was measured | Source | |---|---|---| | Minutes to 2 hours | GH release began within 10 minutes of a nightly injection and lasted about 2 hours | [Khorram, 1997](https://pubmed.ncbi.nlm.nih.gov/9141536/) | | 2 weeks | IGF-1 and IGFBP-3 increased | [Khorram, 1997](https://pubmed.ncbi.nlm.nih.gov/9141536/) | | 2 weeks | In older men, GH and IGF-1 rose to levels similar to young men at the higher dose studied | [Corpas, 1992](https://pubmed.ncbi.nlm.nih.gov/1379256/) | | 6 weeks | 12-hour GH output almost doubled, with no significant change in IGF-1, weight, lean mass or body fat | [Vittone, in this review](https://pmc.ncbi.nlm.nih.gov/articles/PMC7108996/) | | 12 to 16 weeks | IGF-1 stayed raised until 12 weeks, then returned toward baseline by 16 weeks | [Khorram, 1997](https://pubmed.ncbi.nlm.nih.gov/9141536/) | | 16 weeks | Skin thickness increased in both sexes. Lean mass, insulin sensitivity, well-being and libido improved in men only. Weight and sleep quality did not change | [Khorram, 1997](https://pubmed.ncbi.nlm.nih.gov/9141536/) | The Khorram trial used a closely related GHRH analog, not sermorelin itself, and had 19 participants. ## About before-and-after photos Before-and-after results are heavily searched, but a photo cannot separate a medication's effect from diet, training, lighting or other treatments. The studies above used measurements such as body scans for that reason. We do not publish before-and-after photos, and a timeline promising specific changes by a specific week goes beyond this evidence. ## What to track instead Ask your provider about lab monitoring, including IGF-1, and discuss what you hoped to change before you start. That makes it easier to judge whether to continue. Read [does sermorelin work?](/sermorelin/guides/does-it-work/) for the full picture, or [what happens when you stop](/sermorelin/guides/stopping/). ## Common questions ### How quickly will I see results from sermorelin? Lab markers can change within 2 weeks. How soon you might feel or see a difference, if at all, has not been well studied. ### Will I gain weight on sermorelin? Body weight did not change in the adult studies we reviewed. If your weight changes unexpectedly, tell your provider. See [sermorelin and weight loss](/sermorelin/guides/weight-loss/). ### What are the cons of sermorelin? Limited evidence for marketed benefits, a daily injection schedule in the studies, cost, and unknown long-term safety. See [is sermorelin safe?](/sermorelin/guides/is-it-safe/). ### How long do people take it? The adult trials we reviewed lasted 16 weeks or less, so they do not establish an ideal length. Your provider decides this with you. ## Safety at a glance Reported side effects include flushing, injection site pain or irritation and mild headache. Sermorelin is not recommended in pregnancy or breastfeeding, active cancer or certain pituitary conditions, and long-term safety in adults has not been established. It is [prohibited in tested sports](https://www.wada-ama.org/sites/default/files/2024-09/2025list_en_final_clean_12_september_2024.pdf). Read [is sermorelin safe?](/sermorelin/guides/is-it-safe/) for sources and details. ## Keep reading - [All sermorelin guides](/sermorelin/guides/) - [Does sermorelin work?](/sermorelin/guides/does-it-work/): What it does, what studies measured, and who it may suit. - [Stopping sermorelin](/sermorelin/guides/stopping/): What small studies show after stopping, and what isn't known. - [Sermorelin and weight loss](/sermorelin/guides/weight-loss/): Why it isn't an established weight loss treatment, and how it differs from GLP-1s. - [Sermorelin and sleep](/sermorelin/guides/sleep/): The real link between GH and deep sleep, and why it doesn't prove better sleep. **More guides:** [FDA status and legality](/sermorelin/guides/fda-approved-legal/) · [Sermorelin vs tesamorelin](/sermorelin/guides/vs-tesamorelin/) · [Sermorelin online](/sermorelin/guides/online-prescription/) · [Providers compared](/sermorelin/guides/providers-compared/) · [Is sermorelin safe?](/sermorelin/guides/is-it-safe/) · [Sermorelin for women](/sermorelin/guides/for-women/) · [Sermorelin vs CJC-1295](/sermorelin/guides/vs-cjc-1295/) · [Sermorelin vs HGH](/sermorelin/guides/vs-hgh/) · [Sermorelin with GLP-1s](/sermorelin/guides/with-tirzepatide-or-semaglutide/) ## Sources - [Khorram et al., long-term GHRH analog in age-advanced men and women](https://pubmed.ncbi.nlm.nih.gov/9141536/), J Clin Endocrinol Metab, 1997 - [Corpas et al., GHRH-(1-29) twice daily in older men](https://pubmed.ncbi.nlm.nih.gov/1379256/), J Clin Endocrinol Metab, 1992 - [Sinha et al., Beyond the androgen receptor: growth hormone secretagogues](https://pmc.ncbi.nlm.nih.gov/articles/PMC7108996/), Transl Androl Urol, 2020 Published by Astra, which offers sermorelin. This guide is educational and is not medical advice. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness or quality.