# What happens when you stop sermorelin?
Updated November 3, 2026. Canonical: https://try-astra.com/sermorelin/guides/stopping/

**Sermorelin at Astra:** $91/mo on the 6-month plan ($546 every 6 months) or $120/mo on the monthly plan. Includes medication, provider visit, supplies and shipping. Full refund if a provider does not prescribe. Pay by card or Apple Pay, or over time with Klarna, Afterpay or Affirm at checkout. Prescription required. Compounded medications are not FDA-approved. [Start a visit](https://start.try-astra.com/start-online-visit/sermorelin).

## The short answer

**You can stop when you and your provider decide to, and you can cancel your plan at any time.** What happens to your body afterward has barely been studied. In [one small study of older men](https://pmc.ncbi.nlm.nih.gov/articles/PMC7108996/), IGF-1 stayed above baseline 2 weeks after stopping, and we did not find long-term research after that. Any effect tied to treatment may fade, but no good data say how quickly.

## What makes stopping simple

- **Cancel any time.** The [subscription terms](/subscription-terms/) explain how, and when renewals happen.
- **Ask your care team.** You can message them about how to stop and whether follow-up labs make sense.
- **No lock-in on monthly.** The monthly plan is billed one month at a time.

**Considering sermorelin?** A licensed provider reviews your answers and decides whether it is appropriate. See how it compares on price in the [sermorelin price index](/sermorelin-price-index/), or read about the [sermorelin program](/sermorelin/). [Start your sermorelin visit](https://start.try-astra.com/start-online-visit/sermorelin).
$120 charged monthly, or $546 every 6 months ($91/mo). Renews automatically; cancel any time. Full refund if a provider does not prescribe. [Subscription terms](/subscription-terms/).

## What the evidence shows

| Source | What it found | Limit |
|---|---|---|
| [Corpas, 1992](https://pubmed.ncbi.nlm.nih.gov/1379256/), [via this review](https://pmc.ncbi.nlm.nih.gov/articles/PMC7108996/) | IGF-1 stayed above baseline 2 weeks after stopping | 10 older men, short treatment periods |
| [Khorram, 1997](https://pubmed.ncbi.nlm.nih.gov/9141536/) | IGF-1 returned toward baseline by week 16, even during treatment | Suggests the rise may not hold over time; 19 adults on a related analog |

Sermorelin works through the pituitary and normal feedback ([Walker, 2006](https://pubmed.ncbi.nlm.nih.gov/18046908/)), which is different from taking HGH directly. See [sermorelin vs HGH](/sermorelin/guides/vs-hgh/). That design argument does not tell you what you will notice when you stop.

## Before you stop

- Tell your provider why you want to stop, such as cost, side effects or no benefit
- Ask whether follow-up labs make sense
- Check your billing date and how to cancel in the [subscription terms](/subscription-terms/)
- Report any unexpected symptoms rather than assuming they are related

## Common questions

### Are sermorelin results permanent?
No evidence shows they are. The studies we reviewed were short and did not follow people long after treatment ended.

### Do I need to taper off sermorelin?
We found no research on tapering. Ask your provider how to stop in your situation.

### Will my body stop making growth hormone?
We found no study showing this happens after sermorelin, but long-term data are lacking. Discuss any concern with your provider, and see [is sermorelin safe?](/sermorelin/guides/is-it-safe/).

### Can I restart later?
A provider would need to review your health again. Refills and restarts depend on your provider's decision.

## Safety at a glance

Reported side effects include flushing, injection site pain or irritation and mild headache. Sermorelin is not recommended in pregnancy or breastfeeding, active cancer or certain pituitary conditions, and long-term safety in adults has not been established. It is [prohibited in tested sports](https://www.wada-ama.org/sites/default/files/2024-09/2025list_en_final_clean_12_september_2024.pdf). Read [is sermorelin safe?](/sermorelin/guides/is-it-safe/) for sources and details.

## Keep reading

- [All sermorelin guides](/sermorelin/guides/)
- [Results timeline](/sermorelin/guides/results-timeline/): What studies measured over time, and why before-and-after photos mislead.
- [Is sermorelin safe?](/sermorelin/guides/is-it-safe/): Known side effects, who should avoid it, and what remains unknown.
- [Does sermorelin work?](/sermorelin/guides/does-it-work/): What it does, what studies measured, and who it may suit.
- [Sermorelin online](/sermorelin/guides/online-prescription/): Why a licensed US provider beats a research-peptide seller, and how it works.

**More guides:** [FDA status and legality](/sermorelin/guides/fda-approved-legal/) · [Sermorelin vs tesamorelin](/sermorelin/guides/vs-tesamorelin/) · [Providers compared](/sermorelin/guides/providers-compared/) · [Sermorelin for women](/sermorelin/guides/for-women/) · [Sermorelin and weight loss](/sermorelin/guides/weight-loss/) · [Sermorelin vs CJC-1295](/sermorelin/guides/vs-cjc-1295/) · [Sermorelin vs HGH](/sermorelin/guides/vs-hgh/) · [Sermorelin and sleep](/sermorelin/guides/sleep/) · [Sermorelin with GLP-1s](/sermorelin/guides/with-tirzepatide-or-semaglutide/)

## Sources

- [Corpas et al., GHRH-(1-29) twice daily in older men](https://pubmed.ncbi.nlm.nih.gov/1379256/), J Clin Endocrinol Metab, 1992
- [Sinha et al., Beyond the androgen receptor: growth hormone secretagogues](https://pmc.ncbi.nlm.nih.gov/articles/PMC7108996/), Transl Androl Urol, 2020
- [Khorram et al., long-term GHRH analog in age-advanced men and women](https://pubmed.ncbi.nlm.nih.gov/9141536/), J Clin Endocrinol Metab, 1997
- [Walker, Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?](https://pubmed.ncbi.nlm.nih.gov/18046908/), Clin Interv Aging, 2006

Published by Astra, which offers sermorelin. This guide is educational and is not medical advice. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness or quality.