# Can you take sermorelin with tirzepatide or semaglutide? Updated November 3, 2026. Canonical: https://try-astra.com/sermorelin/guides/with-tirzepatide-or-semaglutide/ **Sermorelin at Astra:** $91/mo on the 6-month plan ($546 every 6 months) or $120/mo on the monthly plan. Includes medication, provider visit, supplies and shipping. Full refund if a provider does not prescribe. Pay by card or Apple Pay, or over time with Klarna, Afterpay or Affirm at checkout. Prescription required. Compounded medications are not FDA-approved. [Start a visit](https://start.try-astra.com/start-online-visit/sermorelin). ## The short answer **Possibly, but only with a prescriber who knows about both, because the combination has not been studied.** A PubMed search on November 3, 2026 found no papers on sermorelin with semaglutide, tirzepatide or GLP-1 medications, and Drugs.com lists [a moderate interaction with tirzepatide](https://www.drugs.com/drug-interactions/sermorelin-with-tirzepatide-2055-0-4363-0.html) over blood sugar control. Astra offers these treatments separately, and a provider decides what is appropriate. Compounded medications are not FDA-approved. ## Why one provider helps - **Your full medication list.** A provider reviewing your history can see what you already take, including medication from elsewhere. - **Blood sugar in view.** That matters most if you have diabetes or take glucose-lowering medication. - **A place to ask.** You can message your care team if anything changes after you start. **Considering sermorelin?** A licensed provider reviews your answers and decides whether it is appropriate. See how it compares on price in the [sermorelin price index](/sermorelin-price-index/), or read about the [sermorelin program](/sermorelin/). [Start your sermorelin visit](https://start.try-astra.com/start-online-visit/sermorelin). $120 charged monthly, or $546 every 6 months ($91/mo). Renews automatically; cancel any time. Full refund if a provider does not prescribe. [Subscription terms](/subscription-terms/). ## What is known | Question | What we found | |---|---| | Any trials of the combination? | None found in PubMed on November 3, 2026 | | Interaction listed? | [Moderate, for tirzepatide](https://www.drugs.com/drug-interactions/sermorelin-with-tirzepatide-2055-0-4363-0.html). It may interfere with blood sugar control and reduce the effect of diabetes medications | | Does it help GLP-1 weight loss? | Not shown. Sermorelin did not change body weight in [the adult studies we reviewed](/sermorelin/guides/weight-loss/) | | Does it protect muscle on a GLP-1? | Not shown. We found no study testing this | ## Why blood sugar matters here The label for [tesamorelin](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3d783378-b02d-4f19-99dd-0fc91a042224), a related drug that also raises growth hormone, warns about glucose intolerance. It is not known how far that applies to sermorelin, but it is one reason to involve a prescriber, especially if you have diabetes. Sermorelin raises growth hormone and IGF-1, a hormone the liver makes in response to it. Those are the changes a prescriber may want to watch alongside your blood sugar. ## What to tell your provider - Every medication and supplement you take, including GLP-1 medications from another provider - Whether you have diabetes or take glucose-lowering medication - What you hope combining them would do, so they can tell you whether evidence supports it - Any change in blood sugar, swelling or how you feel after starting Astra offers [compounded tirzepatide](/compound-tirzepatide/), [compounded semaglutide](/compound-semaglutide/) and [sermorelin](/sermorelin/) as separate treatments. A provider decides whether each is appropriate. Compounded medications are not FDA-approved. ## Common questions ### Does sermorelin interact with semaglutide? We did not confirm a semaglutide-specific listing for this page, and we found no studies. The [listed tirzepatide interaction](https://www.drugs.com/drug-interactions/sermorelin-with-tirzepatide-2055-0-4363-0.html) concerns blood sugar control, so raise it with your prescriber for any glucose-lowering medication. ### Do I need to stop my GLP-1 to take sermorelin? Do not stop or change any medication without your prescriber's advice. ### Will sermorelin stop muscle loss on tirzepatide? We found no study showing this, so it should not be assumed. ## Safety at a glance Reported side effects include flushing, injection site pain or irritation and mild headache. Sermorelin is not recommended in pregnancy or breastfeeding, active cancer or certain pituitary conditions, and long-term safety in adults has not been established. It is [prohibited in tested sports](https://www.wada-ama.org/sites/default/files/2024-09/2025list_en_final_clean_12_september_2024.pdf). Read [is sermorelin safe?](/sermorelin/guides/is-it-safe/) for sources and details. ## Keep reading - [All sermorelin guides](/sermorelin/guides/) - [Sermorelin and weight loss](/sermorelin/guides/weight-loss/): Why it isn't an established weight loss treatment, and how it differs from GLP-1s. - [Is sermorelin safe?](/sermorelin/guides/is-it-safe/): Known side effects, who should avoid it, and what remains unknown. - [Does sermorelin work?](/sermorelin/guides/does-it-work/): What it does, what studies measured, and who it may suit. - [Sermorelin online](/sermorelin/guides/online-prescription/): Why a licensed US provider beats a research-peptide seller, and how it works. **More guides:** [FDA status and legality](/sermorelin/guides/fda-approved-legal/) · [Sermorelin vs tesamorelin](/sermorelin/guides/vs-tesamorelin/) · [Providers compared](/sermorelin/guides/providers-compared/) · [Results timeline](/sermorelin/guides/results-timeline/) · [Sermorelin for women](/sermorelin/guides/for-women/) · [Sermorelin vs CJC-1295](/sermorelin/guides/vs-cjc-1295/) · [Sermorelin vs HGH](/sermorelin/guides/vs-hgh/) · [Sermorelin and sleep](/sermorelin/guides/sleep/) · [Stopping sermorelin](/sermorelin/guides/stopping/) ## Sources - [Sermorelin and tirzepatide interaction](https://www.drugs.com/drug-interactions/sermorelin-with-tirzepatide-2055-0-4363-0.html), Drugs.com - [Egrifta SV prescribing information](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3d783378-b02d-4f19-99dd-0fc91a042224), DailyMed - [Khorram et al., long-term GHRH analog in age-advanced men and women](https://pubmed.ncbi.nlm.nih.gov/9141536/), J Clin Endocrinol Metab, 1997 - [Sinha et al., Beyond the androgen receptor: growth hormone secretagogues](https://pmc.ncbi.nlm.nih.gov/articles/PMC7108996/), Transl Androl Urol, 2020 Published by Astra, which offers sermorelin. This guide is educational and is not medical advice. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness or quality.