Key takeaways GLP-1 medication price overview Here’s what every major GLP-1 medication costs in 2026. List prices are the official prices set by the drug manufacturer. Manufacturer direct prices are what you’d pay buying directly from Eli Lilly or Novo Nordisk. TrumpRx prices reflect the new Most-Favored-Nation pricing announced in late 2025. Medication Active Ingredient […]
By Astra Editorial Team
Published:
Updated:
Here’s what every major GLP-1 medication costs in 2026. List prices are the official prices set by the drug manufacturer. Manufacturer direct prices are what you’d pay buying directly from Eli Lilly or Novo Nordisk. TrumpRx prices reflect the new Most-Favored-Nation pricing announced in late 2025.
| Medication | Active Ingredient | Approved For | List price/month | Manufacturer Direct | TrumpRx | With Insurance + Copay Card |
|---|---|---|---|---|---|---|
| Ozempic | Semaglutide | Type 2 diabetes | $1,028 | $349-$499 (NovoCare) | As low as $199 | As low as $25 |
| Wegovy injection | Semaglutide | Weight loss | $1,349 | $199-$349 (NovoCare) | $199-$350 | As low as $25 |
| Wegovy pill | Semaglutide | Weight loss | $1,349 | $199-$299 (NovoCare) | $149-$299 | As low as $25 |
| Mounjaro | Tirzepatide | Type 2 diabetes | $1,112 | Not available direct | As low as $245 (Medicare price) | As low as $25 |
| Zepbound vial | Tirzepatide | Weight loss | $499-$1,086 | $299-$699 (Lilly Direct) | $299-$346 average | As low as $25 |
| Zepbound KwikPen | Tirzepatide | Weight loss | $499-$1,086 | $499-$699 (Lilly Direct) | Up to $699 | As low as $25 |
| Foundayo | Orforglipron (oral) | Weight loss | $149-$349 | $149-$299 (Lilly Direct) | $149-$349 | As low as $25 |
| Saxenda | Liraglutide | Weight loss | $1,349 | Not available direct | Not listed | As low as $25 |
| Compounded semaglutide | Semaglutide | Off-label (503A) | $96-$300 | N/A | N/A | Not covered |
| Compounded tirzepatide | Tirzepatide | Off-label (503A) | $115-$300 | N/A | N/A | Not covered |
Astra’s 3-month starter plan is the most affordable way to try a real GLP-1 protocol: reviewed by a licensed clinician, filled by a US-licensed 503A pharmacy.
Start your health profile →Quick answer: Ozempic costs $25-$1,028 per month in 2026 depending on insurance and how you buy it. The list price is about $1,028 per month, but most people pay $25-$499 through copay cards, NovoCare direct, or TrumpRx.
Ozempic (semaglutide) is approved for type 2 diabetes, and the list price is about $1,028 per month without insurance. That’s what your pharmacy pays the manufacturer. What you’ll actually pay depends on how you get it.
A 3-month supply of Ozempic ranges from $75 (with copay card) to about $3,084 (full list price), with most cash-pay options landing between $597 and $1,047.
Quick answer: Wegovy costs $25-$1,349 per month in 2026 depending on how you buy it. The list price is $1,349 per month, but most people pay $25 (with insurance and a copay card), $199-$349 (NovoCare direct), or $149-$350 (TrumpRx).
Wegovy (semaglutide) is the FDA-approved version of the same active ingredient as Ozempic, but specifically approved for weight loss. The list price is $1,349 per month.
A 30-day supply of Wegovy costs $25 (with copay card), $199-$349 (NovoCare), $149-$350 (TrumpRx), or $1,349 (full list price without any discounts).
The cheapest way to get Wegovy in 2026 is the $25 manufacturer copay card if you have commercial insurance that covers it. The cheapest cash-pay option is the Wegovy pill through TrumpRx at $149-$199 per month.
Quick answer: Zepbound costs $25-$1,086 per month in 2026, with cash-pay options starting at $299 through Lilly Direct. With commercial insurance and a Lilly copay card, you can pay as little as $25 per month. Lilly Direct vials range from $299-$699 depending on dose.
Zepbound (tirzepatide) is approved for weight loss, with list prices ranging from $499 to $1,086 per month depending on dose and format.
A 28-day supply of Zepbound costs $25 (with copay card), $299-$699 (Lilly Direct), $299-$346 (TrumpRx average), or up to $1,086 at full list price.
Zepbound is cheaper than Ozempic at most price points in 2026 if you’re paying cash, mainly because Lilly Direct’s vial pricing starts at $299 versus NovoCare’s $349 for Ozempic. But if you have insurance with copay support, both can land at $25.
Quick answer: Mounjaro costs $25-$1,112 per month in 2026, with no direct cash-pay program like Zepbound has. With commercial insurance and a Lilly copay card, you can pay as little as $25 per month. Without insurance, expect to pay close to the $1,112 list price unless you qualify for the Medicare price ($245) through TrumpRx.
Mounjaro (tirzepatide) is the diabetes-approved version of the same drug as Zepbound. The list price is about $1,112 per month without insurance.
A 3-month supply of Mounjaro ranges from $75 (with copay card) to about $3,336 (full list price).
Quick answer: Compounded GLP-1s typically cost $96-$300 per month through licensed 503A pharmacies, and they’re not covered by insurance. Compounded semaglutide usually runs $96-$200 per month. Compounded tirzepatide runs higher, usually $115-$300 per month. Microdose plans cost less because they use less medication, but they’re a clinical option for specific patients, not a budget tier.
Compounded GLP-1s are made by licensed 503A compounding pharmacies for individual patients with valid prescriptions. They’re more affordable than brand-name GLP-1s because they don’t carry brand pharmaceutical pricing markups.
According to Forbes Health, compounded GLP-1s typically cost $100-$300 per month, with the range reflecting different platforms, doses, and concentrations. Some microdose plans go even lower.
Standard compounded semaglutide pricing in 2026 typically runs $96-$200 per month depending on the platform. Standard compounded tirzepatide runs higher, usually $115-$300 per month.
A few things to know about compounded GLP-1 pricing:
The standard compounded semaglutide at Astra (try-astra.com) starts at $96 per month on the 3-month starter plan. Microdose semaglutide starts at $89 per month on the 6-month plan. Compounded tirzepatide starts at $125 per month on the 12-month plan, with microdose starting at $109 per month on the 6-month plan.
Prices are inclusive of consultation, medication, and ongoing clinical monitoring.
If your insurance covers a GLP-1 and you qualify for a manufacturer copay card, you can pay as little as $25 per month. That’s the most affordable scenario in the entire category. But not all insurance plans cover GLP-1s, especially for weight loss.
Diabetes coverage: GLP-1s like Ozempic, Mounjaro, and Trulicity are widely covered by commercial insurance plans when prescribed for type 2 diabetes. Coverage is more consistent here because the diabetes indication is well-established and FDA-approved for decades.
Weight loss coverage: Only 67% of large employers (5,000+ workers) cover GLP-1s for weight management as of 2026. Of those that do cover them, only 72% plan to continue coverage in 2027. According to a 2026 PSG survey, 49% of payers who don’t currently cover GLP-1s for obesity would not cover them at any price.
If you have commercial insurance and your plan covers Wegovy, Ozempic, Zepbound, or Mounjaro, applying for the manufacturer copay card is the next step. These cards typically bring your cost to $25 per month and are stackable with insurance.
Only about 1 in 5 large employer plans cover GLP-1s for weight loss. If yours doesn’t and manufacturer cash pricing is still out of reach, compounded from a licensed 503A pharmacy starts at $96/month, with a real clinician reviewing your case first.
See what fits your budget →If you’re paying cash, here are your most affordable options ranked by 2026 prices:
The cheapest weight loss injection without insurance in 2026 is compounded semaglutide through a licensed 503A pharmacy, with standard plans starting around $96/month. The cheapest brand-name option is the Wegovy pill through TrumpRx at $149/month.
In order of cheapest to most expensive in 2026:
The Medicare GLP-1 Bridge program at $50/month is the single best deal available in 2026 if you qualify. To qualify, you need Medicare Part D coverage plus a BMI of 27 or higher with a qualifying condition (or BMI of 35+ regardless of other conditions). The program covers Wegovy injection, Wegovy pill, Zepbound KwikPen, and Foundayo. The $50 copay doesn’t change as your dose increases.
The catch with the Bridge program is that the $50 copay won’t count toward your Part D deductible or out-of-pocket cap. The program ends December 31, 2027, with no guarantee of what replaces it.
Yes, but unevenly. The biggest changes are happening through manufacturer direct programs and the TrumpRx Most-Favored-Nation deals, not through traditional insurance.
Mounjaro prices are likely to go down for Medicare beneficiaries in 2026-2027. For everyone else, prices may stay roughly stable through the rest of 2026 with potential drops in 2027.
GLP-1s tend to lose their effect if you come off them. Astra’s pricing is built for the long haul.
Start with a plan you can keep →There’s a financial flip side. A June 2026 NBER study found that middle-aged adults taking GLP-1s for obesity save an average of $192,735 in lifetime medical costs. For people without college degrees, savings rise to $220,000. So while monthly costs are real, the long-term cost calculus may favor staying on treatment if you can afford it.
GLP-1 pricing in 2026 is more accessible than it’s ever been. Whether you should pay $25 or $349 or $96 per month depends on three things: what kind of insurance you have, what specific medication you need, and whether you’re comfortable with brand-name vs. compounded GLP-1.
If you have commercial insurance that covers GLP-1s, the manufacturer copay cards are the cheapest option at $25 per month.
If you have Medicare Part D and qualify for the Bridge program, $50 per month through July 2026-December 2027 is the second-cheapest option.
If you’re paying cash and want brand-name medication, TrumpRx, Lilly Direct, and NovoCare are the most affordable paths starting at $149-$299 per month.
If you’re paying cash and open to compounded GLP-1 from a licensed 503A pharmacy, $96-$200 per month is realistic.
For more on whether compounded GLP-1 is right for you, see our full guide on compounded GLP-1 medications.
If you’re considering compounded GLP-1 treatment, Astra (try-astra.com) prescribes through licensed clinicians at Wasef Health, PC, and fills compounded prescriptions through VialsRx, a US-licensed 503A pharmacy. Compounded semaglutide starts at $96 per month on Astra’s 3-month starter plan. Microdose plans are also available for patients with clinical indications.
Compounded semaglutide from $96/month. Compounded tirzepatide from $166/month. Same active ingredient. Real clinician oversight.
Start your health profile Takes about 5 minutes.To get Ozempic for $25 per month, you need commercial insurance that covers Ozempic plus the Novo Nordisk manufacturer copay card. You can sign up for the copay card directly through Novo Nordisk. Medicare, Medicaid, and other government insurance beneficiaries aren’t eligible for the $25 copay card.
Compounded semaglutide is cheaper than Wegovy if you’re paying cash, but Wegovy is cheaper if you have commercial insurance that covers it. Compounded semaglutide typically costs $96-$200 per month through a 503A pharmacy. Wegovy costs $25 per month with insurance and a copay card, $199-$349 through NovoCare direct, or $149-$350 through TrumpRx.
Wegovy and Saxenda are the most expensive GLP-1s at list price, at $1,349 per month. With insurance, copay cards, or direct purchase programs, what you actually pay is dramatically lower.
Yes, starting July 1, 2026, eligible Medicare Part D beneficiaries can access certain GLP-1 medications for $50 per month through the Medicare GLP-1 Bridge program. The program runs through December 31, 2027. To qualify, you need a BMI of 27+ with a qualifying condition (or BMI of 35+ regardless). Covered medications include Wegovy injection, Wegovy pill, Zepbound KwikPen, and Foundayo.
Ozempic is slightly cheaper at list price ($1,028 vs. $1,112 for Mounjaro). Both can be as low as $25 per month with insurance and a copay card, or $245 per month for Medicare beneficiaries through TrumpRx.
Most people pay between $200 and $500 per month for a GLP-1 in 2026. The full range is $25 (with insurance and copay card) to $1,500 (full list price for some drugs). Where you fall depends on insurance, which medication you take, and whether you use brand-name or compounded.
Yes, if your insurance covers it. The $25 manufacturer copay card with commercial insurance is the cheapest way to get a brand-name GLP-1. If your insurance doesn’t cover the GLP-1 you want, paying cash through TrumpRx, Lilly Direct, NovoCare, or a compounded platform can be cheaper than out-of-pocket brand pricing.
This article is for educational purposes only and does not constitute medical advice. Consult a licensed physician regarding any medical condition or treatment.